Some cases are associated with reciprocal translocation between chromosomes or maternal illness.
2.
A unique feature of this species is its tendency to have widespread reciprocal translocations.
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A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia.
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Polymorphic variants and a reciprocal translocation t ( 6; 8 ) ( q26; q13 ) involving this gene, have been associated with Duane retraction syndrome.
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The reciprocal translocation t ( 1; 3 ) ( p36; q21 ) occurs in a subset of myelodysplastic syndrome ( MDS ) and acute myeloid leukemia ( AML ).
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One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.
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Short telomeres can lead to genomic instability, chromosome loss and the formation of non-reciprocal translocations; and telomeres in tumor cells and their precursor lesions are significantly shorter than surrounding normal tissue.
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In genetics, "'pseudolinkage "'is a characteristic of a heterozygote for a reciprocal translocation, in which genes located near the linked even though they originated on nonhomologous chromosomes.
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One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins.
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Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.
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